Reaction Details |
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Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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Ligand | BDBM50340449 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_741128 (CHEMBL1764399) |
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IC50 | >2000±n/a nM |
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Citation | Venier, O; Pascal, C; Braun, A; Namane, C; Mougenot, P; Crespin, O; Pacquet, F; Mougenot, C; Monseau, C; Onofri, B; Dadji-Faïhun, R; Leger, C; Ben-Hassine, M; Van-Pham, T; Ragot, JL; Philippo, C; Güssregen, S; Engel, C; Farjot, G; Noah, L; Maniani, K; Nicolaï, E Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1. Bioorg Med Chem Lett21:2244-51 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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11-beta-hydroxysteroid dehydrogenase 1 |
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Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
Type: | Enzyme |
Mol. Mass.: | 32409.16 |
Organism: | Homo sapiens (Human) |
Description: | P28845 |
Residue: | 292 |
Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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BDBM50340449 |
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n/a |
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Name | BDBM50340449 |
Synonyms: | (4-(1H-imidazol-2-yl)piperidin-1-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone | CHEMBL1761845 |
Type | Small organic molecule |
Emp. Form. | C18H22N4O |
Mol. Mass. | 310.3935 |
SMILES | O=C(N1CCC(CC1)c1ncc[nH]1)N1CCCc2ccccc12 |
Structure |
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