Reaction Details |
| Report a problem with these data |
Target | 11-beta-hydroxysteroid dehydrogenase 1 |
---|
Ligand | BDBM50340457 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_741128 (CHEMBL1764399) |
---|
IC50 | 200±n/a nM |
---|
Citation | Venier, O; Pascal, C; Braun, A; Namane, C; Mougenot, P; Crespin, O; Pacquet, F; Mougenot, C; Monseau, C; Onofri, B; Dadji-Faïhun, R; Leger, C; Ben-Hassine, M; Van-Pham, T; Ragot, JL; Philippo, C; Güssregen, S; Engel, C; Farjot, G; Noah, L; Maniani, K; Nicolaï, E Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1. Bioorg Med Chem Lett21:2244-51 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
11-beta-hydroxysteroid dehydrogenase 1 |
---|
Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
Type: | Enzyme |
Mol. Mass.: | 32409.16 |
Organism: | Homo sapiens (Human) |
Description: | P28845 |
Residue: | 292 |
Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
|
|
|
BDBM50340457 |
---|
n/a |
---|
Name | BDBM50340457 |
Synonyms: | CHEMBL1761858 | Exo-((1R,5S)-3-(1H-pyrazol-3-yl)-8-azabicyclo[3.2.1]octan-8-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone |
Type | Small organic molecule |
Emp. Form. | C20H24N4O |
Mol. Mass. | 336.4308 |
SMILES | O=C(N1[C@H]2CC[C@@H]1C[C@H](C2)c1ccn[nH]1)N1CCCc2ccccc12 |r,THB:1:2:7.8.9:4.5| |
Structure |
|