| Reaction Details |
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 | Report a problem with these data |
| Target | Steroidogenic factor 1 |
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| Ligand | BDBM22385 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_743680 (CHEMBL1767449) |
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| EC50 | 39.81±n/a nM |
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| Citation |  Whitby, RJ; Stec, J; Blind, RD; Dixon, S; Leesnitzer, LM; Orband-Miller, LA; Williams, SP; Willson, TM; Xu, R; Zuercher, WJ; Cai, F; Ingraham, HA Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem54:2266-81 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Steroidogenic factor 1 |
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| Name: | Steroidogenic factor 1 |
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| Synonyms: | AD4BP | Adrenal 4-binding protein | FTZF1 | Fushi tarazu factor homolog 1 | NR5A1 | Nuclear receptor subfamily 5 group A member 1 | SF-1 | SF1 | STF-1 | STF1_HUMAN | Steroid hormone receptor Ad4BP |
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| Type: | Nuclear Hormone Receptor |
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| Mol. Mass.: | 51643.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 461 |
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| Sequence: | MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKT
QRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKL
ETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPL
AGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQV
RARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQN
CWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLA
LQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLL
LCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
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| BDBM22385 |
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| n/a |
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| Name | BDBM22385 |
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| Synonyms: | (3aS,6aR)-5-hexyl-N,4-diphenyl-1,2,3,3a,6,6a-hexahydropentalen-3a-amine | bicyclo[3.3.0]-oct-2-ene, 5m |
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| Type | Small organic molecule |
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| Emp. Form. | C26H33N |
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| Mol. Mass. | 359.5469 |
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| SMILES | [H][C@]12CCC[C@@]1(Nc1ccccc1)C(=C(CCCCCC)C2)c1ccccc1 |r,t:15| |
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| Structure | 
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