| Reaction Details |
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 | Report a problem with these data |
| Target | Choline kinase alpha |
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| Ligand | BDBM50131885 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_745143 (CHEMBL1772322) |
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| IC50 | 300±n/a nM |
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| Citation |  Conejo-García, A; Pisani, L; Núñez, Mdel C; Catto, M; Nicolotti, O; Leonetti, F; Campos, JM; Gallo, MA; Espinosa, A; Carotti, A Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity. J Med Chem54:2627-45 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Choline kinase alpha |
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| Name: | Choline kinase alpha |
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| Synonyms: | CHK | CHKA | CHKA_HUMAN | CKI | Choline kinase alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52248.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1290064 |
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| Residue: | 457 |
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| Sequence: | MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPP
PPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGL
SNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLE
SVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKM
PFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPV
VFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYP
FFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLW
GLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
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| BDBM50131885 |
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| n/a |
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| Name | BDBM50131885 |
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| Synonyms: | 4,8-diaza-3 (1,4) , 9 (4,1)-dipyridina-1 (1,4), 6 (1,3) -dibenzenacyclodecaphan-3,9-bis (ilium) dibromide | CHEMBL125148 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26N4 |
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| Mol. Mass. | 394.5103 |
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| SMILES | C1N[c+]2ccn(Cc3ccc(Cn4cc[c+](NCc5cccc1c5)cc4)cc3)cc2 |
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| Structure | 
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