| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 10 |
|---|
| Ligand | BDBM50343674 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_745965 (CHEMBL1775264) |
|---|
| IC50 | >30000±n/a nM |
|---|
| Citation |  Kim, S; Jung, JK; Lee, HS; Kim, Y; Kim, J; Choi, K; Baek, DJ; Moon, B; Oh, KS; Lee, BH; Shin, KJ; Pae, AN; Nam, G; Roh, EJ; Cho, YS; Choo, H Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors. Bioorg Med Chem Lett21:3002-6 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 10 |
|---|
| Name: | Mitogen-activated protein kinase 10 |
|---|
| Synonyms: | JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52586.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 464 |
|---|
| Sequence: | MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
|
|
|
|---|
| BDBM50343674 |
|---|
| n/a |
|---|
| Name | BDBM50343674 |
|---|
| Synonyms: | 4-(4-(piperazin-1-ylsulfonyl)phenyl)-N-(piperidin-4-yl)pyrimidin-2-amine | CHEMBL1773334 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H26N6O2S |
|---|
| Mol. Mass. | 402.514 |
|---|
| SMILES | O=S(=O)(N1CCNCC1)c1ccc(cc1)-c1ccnc(NC2CCNCC2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
