| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50344145 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_748047 (CHEMBL1781588) |
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| EC50 | 30±n/a nM |
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| Citation |  Pike, KG; Allen, JV; Caulkett, PW; Clarke, DS; Donald, CS; Fenwick, ML; Johnson, KM; Johnstone, C; McKerrecher, D; Rayner, JW; Walker, RP; Wilson, I Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life. Bioorg Med Chem Lett21:3467-70 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50344145 |
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| n/a |
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| Name | BDBM50344145 |
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| Synonyms: | 6-(3-((S)-1-(5-chlorofuran-2-yl)propan-2-yloxy)-5-((S)-1-methoxypropan-2-yloxy)benzamido)nicotinic acid | CHEMBL1778357 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25ClN2O7 |
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| Mol. Mass. | 488.918 |
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| SMILES | COC[C@H](C)Oc1cc(O[C@@H](C)Cc2ccc(Cl)o2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O |r| |
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| Structure | 
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