Reaction Details |
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Target | Hexokinase-4 |
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Ligand | BDBM50344151 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_748047 (CHEMBL1781588) |
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EC50 | 100±n/a nM |
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Citation | Pike, KG; Allen, JV; Caulkett, PW; Clarke, DS; Donald, CS; Fenwick, ML; Johnson, KM; Johnstone, C; McKerrecher, D; Rayner, JW; Walker, RP; Wilson, I Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life. Bioorg Med Chem Lett21:3467-70 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hexokinase-4 |
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Name: | Hexokinase-4 |
Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
Type: | Enzyme |
Mol. Mass.: | 52175.81 |
Organism: | Homo sapiens (Human) |
Description: | P35557 |
Residue: | 465 |
Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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BDBM50344151 |
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n/a |
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Name | BDBM50344151 |
Synonyms: | 6-(3-(2,3-dihydro-1H-inden-2-yloxy)-5-isopropoxybenzamido)nicotinic acid | CHEMBL1778363 |
Type | Small organic molecule |
Emp. Form. | C25H24N2O5 |
Mol. Mass. | 432.4685 |
SMILES | CC(C)Oc1cc(OC2Cc3ccccc3C2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O |
Structure |
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