Reaction Details |
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Target | Hexokinase-4 |
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Ligand | BDBM50183221 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_748047 (CHEMBL1781588) |
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EC50 | 150±n/a nM |
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Citation | Pike, KG; Allen, JV; Caulkett, PW; Clarke, DS; Donald, CS; Fenwick, ML; Johnson, KM; Johnstone, C; McKerrecher, D; Rayner, JW; Walker, RP; Wilson, I Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life. Bioorg Med Chem Lett21:3467-70 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hexokinase-4 |
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Name: | Hexokinase-4 |
Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
Type: | Enzyme |
Mol. Mass.: | 52175.81 |
Organism: | Homo sapiens (Human) |
Description: | P35557 |
Residue: | 465 |
Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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BDBM50183221 |
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n/a |
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Name | BDBM50183221 |
Synonyms: | (S)-6-(3-isopropoxy-5-(1-phenylethoxy)benzamido)nicotinic acid | CHEMBL379153 |
Type | Small organic molecule |
Emp. Form. | C24H24N2O5 |
Mol. Mass. | 420.4578 |
SMILES | CC(C)Oc1cc(O[C@@H](C)c2ccccc2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O |
Structure |
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