| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 2 |
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| Ligand | BDBM50344689 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_749005 (CHEMBL1781790) |
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| IC50 | 9800±n/a nM |
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| Citation |  Du, X; Lizarzaburu, M; Turcotte, S; Lee, T; Greenberg, J; Shan, B; Fan, P; Ling, Y; Medina, JC; Houze, J Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors. Bioorg Med Chem Lett21:3774-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/glucose cotransporter 2 |
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| Name: | Sodium/glucose cotransporter 2 |
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| Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
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| Type: | Protein |
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| Mol. Mass.: | 72902.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31639 |
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| Residue: | 672 |
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| Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
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| BDBM50344689 |
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| n/a |
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| Name | BDBM50344689 |
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| Synonyms: | CHEMBL1779206 | N-(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-trifluoropropyl)-4H-1,2,4-triazol-3-yl)methyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22Cl2F3N5O3 |
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| Mol. Mass. | 556.364 |
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| SMILES | CC(=O)Nc1cc(Cl)cc2N(Cc3nnc(CCc4ccc(Cl)cc4)n3CCC(F)(F)F)C(=O)COc12 |
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| Structure | 
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