| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 6 |
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| Ligand | BDBM50345758 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_750637 (CHEMBL1785483) |
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| Ki | 2.58±n/a nM |
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| Citation |  Nirogi, RV; Kothmirkar, P; Kambhampati, R; Konda, JB; Arepalli, S; Pamuleti, NG; Deshpande, AD; Bandyala, T; Shinde, AK; Dubey, PK Novel and Potent 5-Piperazinyl Methyl-N 1-aryl Sulfonyl Indole Derivatives as 5-HT6 Receptor Ligands. ACS Med Chem Lett1:340-344 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 6 |
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| Name: | 5-hydroxytryptamine receptor 6 |
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| Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46968.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50406 |
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| Residue: | 440 |
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| Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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| BDBM50345758 |
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| n/a |
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| Name | BDBM50345758 |
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| Synonyms: | 3-chloro-1-(4-fluoro benzenesulfonyl)-5-(piperazin-1-yl-methyl)-1H-indole | CHEMBL1785070 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19ClFN3O2S |
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| Mol. Mass. | 407.889 |
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| SMILES | Fc1ccc(cc1)S(=O)(=O)n1cc(Cl)c2cc(CN3CCNCC3)ccc12 |
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| Structure | 
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