Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50345760 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_750637 (CHEMBL1785483) |
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Ki | 2.52±n/a nM |
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Citation | Nirogi, RV; Kothmirkar, P; Kambhampati, R; Konda, JB; Arepalli, S; Pamuleti, NG; Deshpande, AD; Bandyala, T; Shinde, AK; Dubey, PK Novel and Potent 5-Piperazinyl Methyl-N 1-aryl Sulfonyl Indole Derivatives as 5-HT6 Receptor Ligands. ACS Med Chem Lett1:340-344 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50345760 |
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n/a |
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Name | BDBM50345760 |
Synonyms: | 1-(Benzenesulfonyl)-5-(piperazin-1-yl-methyl)-1H-indole | CHEMBL1785068 |
Type | Small organic molecule |
Emp. Form. | C19H21N3O2S |
Mol. Mass. | 355.454 |
SMILES | O=S(=O)(c1ccccc1)n1ccc2cc(CN3CCNCC3)ccc12 |
Structure |
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