| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 4 |
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| Ligand | BDBM50346918 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_753061 (CHEMBL1798989) |
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| IC50 | >10000±n/a nM |
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| Citation |  Devadas, B; Selness, SR; Xing, L; Madsen, HM; Marrufo, LD; Shieh, H; Messing, DM; Yang, JZ; Morgan, HM; Anderson, GD; Webb, EG; Zhang, J; Devraj, RV; Monahan, JB Substituted N-aryl-6-pyrimidinones: a new class of potent, selective, and orally active p38 MAP kinase inhibitors. Bioorg Med Chem Lett21:3856-60 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 4 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 4 |
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| Synonyms: | JNK-activating kinase 1 | JNKK | JNKK1 | MAP kinase kinase 4 | MAP2K4 | MEK4 | MKK4 | MP2K4_HUMAN | PRKMK4 | SAPK/ERK kinase 1 | SEK1 | SERK1 | SKK1 | c-Jun N-terminal kinase kinase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44294.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1460558 |
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| Residue: | 399 |
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| Sequence: | MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT
LNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV
HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL
MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS
GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE
LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
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| BDBM50346918 |
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| n/a |
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| Name | BDBM50346918 |
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| Synonyms: | CHEMBL1738710 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18ClF2N3O4 |
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| Mol. Mass. | 449.835 |
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| SMILES | Cc1ccc(cc1-n1cnc(OCc2ccc(F)cc2F)c(Cl)c1=O)C(=O)NCCO |
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| Structure | 
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