| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50348225 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_757224 (CHEMBL1803523) |
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| IC50 | 266±n/a nM |
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| Citation |  Smith, CJ; Ali, A; Hammond, ML; Li, H; Lu, Z; Napolitano, J; Taylor, GE; Thompson, CF; Anderson, MS; Chen, Y; Eveland, SS; Guo, Q; Hyland, SA; Milot, DP; Sparrow, CP; Wright, SD; Cumiskey, AM; Latham, M; Peterson, LB; Rosa, R; Pivnichny, JV; Tong, X; Xu, SS; Sinclair, PJ Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib. J Med Chem54:4880-95 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50348225 |
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| n/a |
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| Name | BDBM50348225 |
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| Synonyms: | CHEMBL1800805 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H26F9NO3 |
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| Mol. Mass. | 619.518 |
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| SMILES | COc1ccc(cc1-c1ccc(cc1CN1[C@H](C)[C@H](OC1=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(F)(F)F)C(C)C |r| |
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| Structure | 
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