| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 1A2 |
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| Ligand | BDBM50348422 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_755265 (CHEMBL1804119) |
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| IC50 | >10000±n/a nM |
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| Citation |  Morgan, BP; Muci, A; Lu, PP; Qian, X; Tochimoto, T; Smith, WW; Garard, M; Kraynack, E; Collibee, S; Suehiro, I; Tomasi, A; Valdez, SC; Wang, W; Jiang, H; Hartman, J; Rodriguez, HM; Kawas, R; Sylvester, S; Elias, KA; Godinez, G; Lee, K; Anderson, R; Sueoka, S; Xu, D; Wang, Z; Djordjevic, N; Malik, FI; Morgans, DJ Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin. ACS Med Chem Lett1:472-477 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 1A2 |
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| Name: | Cytochrome P450 1A2 |
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| Synonyms: | CP1A2_HUMAN | CYP1A2 | CYPIA2 | Cholesterol 25-hydroxylase | Cytochrome P(3)450 | Cytochrome P450 1A | Cytochrome P450 1A2 (CYP1A2) | Cytochrome P450 4 | Cytochrome P450-P3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 58423.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05177 |
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| Residue: | 516 |
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| Sequence: | MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
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| BDBM50348422 |
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| n/a |
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| Name | BDBM50348422 |
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| Synonyms: | CHEMBL1800954 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25N5O3 |
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| Mol. Mass. | 383.4442 |
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| SMILES | COC(=O)N1CCN(Cc2cccc(NC(=O)Nc3ccc(C)nc3)c2)CC1 |
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| Structure | 
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