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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Acetyl-CoA carboxylase 2 | ||
| Ligand | BDBM50350741 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_762997 (CHEMBL1820814) | ||
| IC50 | 1300±n/a nM | ||
| Citation |  Bengtsson, C; Blaho, S; Saitton, DB; Brickmann, K; Broddefalk, J; Davidsson, O; Drmota, T; Folmer, R; Hallberg, K; Hallén, S; Hovland, R; Isin, E; Johannesson, P; Kull, B; Larsson, LO; Löfgren, L; Nilsson, KE; Noeske, T; Oakes, N; Plowright, AT; Schnecke, V; Ståhlberg, P; Sörme, P; Wan, H; Wellner, E; Oster, L Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorg Med Chem19:3039-53 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Acetyl-CoA carboxylase 2 | |||
| Name: | Acetyl-CoA carboxylase 2 | ||
| Synonyms: | ACACB | ACACB_HUMAN | ACC-beta | ACC2 | ACCB | Acetyl-CoA carboxylase | Acetyl-CoA carboxylase 2 | Acetyl-CoA carboxylase 2 (ACC) | Acetyl-CoA carboxylase 2 (ACC2) | ||
| Type: | Protein | ||
| Mol. Mass.: | 276535.21 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00763 | ||
| Residue: | 2458 | ||
| Sequence: |
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| BDBM50350741 | |||
| n/a | |||
| Name | BDBM50350741 | ||
| Synonyms: | CHEMBL1818290 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H39N5O3 | ||
| Mol. Mass. | 481.6303 | ||
| SMILES | CC(C)(C)OC(=O)NC[C@H]1CC[C@H](CNC(=O)c2cc(nc3ccccc23)N2CCNCC2)CC1 |r,wU:9.8,wD:12.12,(47.1,-29.44,;48.43,-28.67,;48.42,-27.13,;47.09,-27.9,;49.76,-29.44,;51.1,-28.66,;51.09,-27.12,;52.43,-29.43,;52.44,-30.97,;53.78,-31.74,;55.11,-30.96,;56.44,-31.74,;56.44,-33.28,;57.77,-34.05,;57.77,-35.59,;59.1,-36.37,;60.44,-35.6,;59.1,-37.91,;60.43,-38.67,;60.44,-40.21,;59.09,-40.98,;57.76,-40.21,;56.44,-40.97,;55.11,-40.21,;55.11,-38.67,;56.45,-37.9,;57.77,-38.68,;61.76,-40.97,;61.77,-42.52,;63.1,-43.28,;64.44,-42.51,;64.43,-40.96,;63.09,-40.2,;55.11,-34.04,;53.78,-33.28,)| | ||
| Structure | 
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