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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Acetyl-CoA carboxylase 2 | ||
| Ligand | BDBM50350753 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_762997 (CHEMBL1820814) | ||
| IC50 | 130±n/a nM | ||
| Citation |  Bengtsson, C; Blaho, S; Saitton, DB; Brickmann, K; Broddefalk, J; Davidsson, O; Drmota, T; Folmer, R; Hallberg, K; Hallén, S; Hovland, R; Isin, E; Johannesson, P; Kull, B; Larsson, LO; Löfgren, L; Nilsson, KE; Noeske, T; Oakes, N; Plowright, AT; Schnecke, V; Ståhlberg, P; Sörme, P; Wan, H; Wellner, E; Oster, L Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorg Med Chem19:3039-53 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Acetyl-CoA carboxylase 2 | |||
| Name: | Acetyl-CoA carboxylase 2 | ||
| Synonyms: | ACACB | ACACB_HUMAN | ACC-beta | ACC2 | ACCB | Acetyl-CoA carboxylase | Acetyl-CoA carboxylase 2 | Acetyl-CoA carboxylase 2 (ACC) | Acetyl-CoA carboxylase 2 (ACC2) | ||
| Type: | Protein | ||
| Mol. Mass.: | 276535.21 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00763 | ||
| Residue: | 2458 | ||
| Sequence: |
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| BDBM50350753 | |||
| n/a | |||
| Name | BDBM50350753 | ||
| Synonyms: | CHEMBL1818303 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H51N5O3 | ||
| Mol. Mass. | 565.7897 | ||
| SMILES | CN(C)CCC1CCN(CC1)c1cc(C(=O)NC[C@H]2CC[C@H](CNC(=O)OCC(C)(C)C)CC2)c2ccccc2n1 |r,wU:21.22,wD:18.18,(58.23,-15.48,;58.23,-13.94,;59.57,-13.17,;56.9,-13.17,;56.9,-11.63,;55.57,-10.86,;54.23,-11.62,;52.9,-10.86,;52.91,-9.33,;54.23,-8.54,;55.57,-9.31,;51.57,-8.56,;51.56,-7.01,;50.23,-6.25,;50.22,-4.71,;51.55,-3.94,;48.88,-3.95,;48.87,-2.41,;47.54,-1.65,;47.53,-.1,;46.2,.66,;44.86,-.11,;43.53,.66,;43.53,2.2,;42.19,2.97,;42.19,4.51,;40.86,2.2,;39.52,2.96,;38.19,2.19,;36.86,2.96,;38.19,.65,;36.85,1.43,;44.87,-1.65,;46.2,-2.42,;48.9,-7.03,;47.57,-6.26,;46.24,-7.03,;46.24,-8.58,;47.57,-9.35,;48.9,-8.57,;50.24,-9.33,)| | ||
| Structure | 
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