Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetLow affinity sodium-glucose cotransporter
LigandBDBM50351443
Substrate/Competitorn/a
Meas. Tech.ChEMBL_764617
IC50 120±n/a nM
Citation Ohtake YSato TMatsuoka HNishimoto MTaka NTakano KYamamoto KOhmori MHiguchi TMurakata MKobayashi TMorikawa KShimma NSuzuki MHagita HOzawa KYamaguchi KKato MIkeda S 5a-Carba-ß-D-glucopyranose derivatives as novel sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem 19:5334-41 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Low affinity sodium-glucose cotransporter
Name:Low affinity sodium-glucose cotransporter
Synonyms:Na(+)/glucose cotransporter 3 | Sodium/glucose cotransporter 3 | Solute carrier family 5 member 4
Type:PROTEIN
Mol. Mass.:72452.26
Organism:Homo sapiens (Human)
Description:ChEMBL_764617
Residue:659
Sequence:
MASTVSPSTIAETPEPPPLSDHIRNAADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFL
AGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIY
IKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLA
IFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNAT
PSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQR
CLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVG
CTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEK
ELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRV
NEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLV
TLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKSQEETDDGVEEDYPEKSRGCLK
KAYDLFCGLQKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50351443
n/a
NameBDBM50351443
Synonyms:CHEMBL1819496
TypeSmall organic molecule
Emp. Form.C21H23F3O5
Mol. Mass.412.3995
SMILESOC[C@H]1C[C@@H](Oc2ccccc2Cc2ccc(cc2)C(F)(F)F)[C@H](O)[C@@H](O)[C@@H]1O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: