| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
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| Ligand | BDBM50354681 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_771237 (CHEMBL1839319) |
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| IC50 | 39±n/a nM |
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| Citation |  Ramtohul, YK; Powell, D; Leclerc, JP; Leger, S; Oballa, R; Black, C; Isabel, E; Li, CS; Crane, S; Robichaud, J; Guay, J; Guiral, S; Zhang, L; Huang, Z Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors. Bioorg Med Chem Lett21:5692-6 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA desaturase 1 |
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| Name: | Acyl-CoA desaturase 1 |
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| Synonyms: | ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41485.97 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P07308 |
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| Residue: | 358 |
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| Sequence: | MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
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| BDBM50354681 |
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| n/a |
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| Name | BDBM50354681 |
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| Synonyms: | CHEMBL1834447 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17F3N6O |
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| Mol. Mass. | 378.3517 |
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| SMILES | Nc1ncnc2nc([nH]c12)N1CCC(CC1)Oc1ccccc1C(F)(F)F |
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| Structure | 
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