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TargetCaspase-2
LigandBDBM50355110
Substrate/Competitorn/a
Meas. Tech.ChEMBL_773166
IC50 41±n/a nM
Citation Maillard MCBrookfield FACourtney SMEustache FMGemkow MJHandel RKJohnson LCJohnson PDKerry MAKrieger FMeniconi MMuñoz-Sanjuán IPalfrey JJPark HSchaertl STaylor MGWeddell DDominguez C Exploiting differences in caspase-2 and -3 S2 subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors. Bioorg Med Chem 19:5833-51 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Caspase-2
Name:Caspase-2
Synonyms:CASP-2 | Caspase-2 subunit p12 | Caspase-2 subunit p13 | Caspase-2 subunit p18 | ICH-1 protease | ICH-1L/1S | NEDD-2 | Neural precursor cell expressed developmentally down-regulated protein 2
Type:Enzyme
Mol. Mass.:50688.29
Organism:Homo sapiens (Human)
Description:P42575
Residue:452
Sequence:
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL
LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT
TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT
PEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV
HVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF
DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPT
RSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGY
APGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
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  Blast E-value cutoff:
BDBM50355110
n/a
NameBDBM50355110
Synonyms:CHEMBL1835208
TypeSmall organic molecule
Emp. Form.C27H45N5O11
Mol. Mass.615.6731
SMILESCC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](COC(C)(C)C)C(=O)N[C@H]1CC(=O)OC1O |r|
Structure
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