Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50355147 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_772696 (CHEMBL1837164) | ||
IC50 | 175±n/a nM | ||
Citation | Dow, RL; Andrews, M; Aspnes, GE; Balan, G; Michael Gibbs, E; Guzman-Perez, A; Karki, K; Laperle, JL; Li, JC; Litchfield, J; Munchhof, MJ; Perreault, C; Patel, L Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett21:6122-5 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Protein | ||
Mol. Mass.: | 55297.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75907 | ||
Residue: | 488 | ||
Sequence: |
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BDBM50355147 | |||
n/a | |||
Name | BDBM50355147 | ||
Synonyms: | CHEMBL1834556 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H22N4O2 | ||
Mol. Mass. | 350.4143 | ||
SMILES | Nc1ncnc2OC[C@@H](Oc12)c1ccc(cc1)[C@H]1CC[C@H](CC#N)CC1 |r,wU:8.12,17.19,wD:20.23,(-8.65,-22.04,;-8.64,-23.58,;-9.97,-24.35,;-9.98,-25.9,;-8.64,-26.67,;-7.3,-25.9,;-5.96,-26.67,;-4.62,-25.88,;-4.62,-24.34,;-5.97,-23.56,;-7.31,-24.35,;-3.3,-23.57,;-1.96,-24.33,;-.63,-23.54,;-.65,-22,;-2,-21.25,;-3.32,-22.04,;.67,-21.22,;.65,-19.68,;1.98,-18.9,;3.32,-19.66,;4.65,-18.88,;4.63,-17.34,;4.61,-15.8,;3.33,-21.2,;2.01,-21.98,)| | ||
Structure |