| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50355375 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_773130 (CHEMBL1838100) |
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| Ki | 120±n/a nM |
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| Citation |  Vardanyan, R; Kumirov, VK; Nichol, GS; Davis, P; Liktor-Busa, E; Rankin, D; Varga, E; Vanderah, T; Porreca, F; Lai, J; Hruby, VJ Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands. Bioorg Med Chem19:6135-42 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44503.11 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
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| Residue: | 398 |
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| Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM50355375 |
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| n/a |
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| Name | BDBM50355375 |
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| Synonyms: | CHEMBL1835844 |
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| Type | Small organic molecule |
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| Emp. Form. | C44H44F6N4O4 |
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| Mol. Mass. | 806.835 |
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| SMILES | FC(F)(F)c1cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CCCC(=O)N(C2CCN(CCc3ccccc3)CC2)c2ccccc2)cc(c1)C(F)(F)F |r| |
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| Structure | 
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