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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Rho-associated protein kinase 2 | ||
| Ligand | BDBM6568 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_774449 (CHEMBL1908666) | ||
| Kd | >10000±n/a nM | ||
| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Rho-associated protein kinase 2 | |||
| Name: | Rho-associated protein kinase 2 | ||
| Synonyms: | KIAA0619 | ROCK-II | ROCK2 | ROCK2_HUMAN | Rho kinase 2 (ROCKII) | Rho-associated protein kinase 2 (ROCK-2) | Rho-associated protein kinase 2 (ROCK2) | Rho-associated protein kinase 2 (ROCKII) | Rho-associated protein kinase 2/Transforming protein RhoA | Rho-associated, coiled-coil-containing protein kinase 2 | Rho-associated, coiled-coil-containing protein kinase II | Serine/threonine-protein kinase RIO2 | p164 ROCK-2 | ||
| Type: | Protein | ||
| Mol. Mass.: | 160885.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75116 | ||
| Residue: | 1388 | ||
| Sequence: |
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| BDBM6568 | |||
| n/a | |||
| Name | BDBM6568 | ||
| Synonyms: | 6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL386051 | PD-173955 | PD173955 | US11136333, Compound PD173955 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H16Cl2N4OS | ||
| Mol. Mass. | 443.349 | ||
| SMILES | CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 |(-12.18,1.86,;-10.84,1.09,;-9.51,1.86,;-9.51,3.4,;-8.18,4.17,;-6.84,3.4,;-6.84,1.86,;-5.51,1.08,;-4.18,1.85,;-4.18,3.39,;-2.84,4.16,;-1.51,3.4,;-.18,4.17,;1.16,3.4,;2.49,4.17,;2.49,5.71,;1.16,6.48,;3.83,6.48,;5.16,5.71,;5.16,4.17,;3.83,3.39,;3.83,1.85,;1.16,1.86,;2.49,1.09,;-.18,1.09,;-.18,-.45,;-1.51,1.86,;-2.84,1.08,;-8.18,1.08,)| | ||
| Structure | 
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