| Reaction Details |
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 | Report a problem with these data |
| Target | Activin receptor type-2B |
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| Ligand | BDBM32362 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774300 (CHEMBL1908517) |
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| Kd | >10000±n/a nM |
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| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Activin receptor type-2B |
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| Name: | Activin receptor type-2B |
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| Synonyms: | ACVR2B | AVR2B_HUMAN | Activin receptor type-2B |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57713.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_116734708 |
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| Residue: | 512 |
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| Sequence: | MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY
ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG
GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP
PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK
HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY
LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG
TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ
HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL
IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
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| BDBM32362 |
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| n/a |
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| Name | BDBM32362 |
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| Synonyms: | 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine | GW-2580 | [2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine | cid_11617559 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N4O3 |
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| Mol. Mass. | 366.4137 |
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| SMILES | COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 |
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| Structure | 
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