| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Nek3 |
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| Ligand | BDBM50355501 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774350 (CHEMBL1908567) |
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| Kd | 1100±n/a nM |
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| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Nek3 |
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| Name: | Serine/threonine-protein kinase Nek3 |
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| Synonyms: | NEK3 | NEK3_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57709.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774350 |
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| Residue: | 506 |
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| Sequence: | MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP
NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK
KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN
NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR
NPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRI
ALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHR
RQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILK
NADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTD
FEEEDDNPDWVSELKKRAGWQGLCDR
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| BDBM50355501 |
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| n/a |
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| Name | BDBM50355501 |
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| Synonyms: | INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE | US10112907, Example 00016 | US10766894, Compound TABLE 1.1 | US10875847, Compound JAKAFI | US11203595, TABLE 1.1 | US11279703, TABLE 6.147 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N6 |
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| Mol. Mass. | 306.365 |
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| SMILES | N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 |r| |
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| Structure | 
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