| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 16 |
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| Ligand | BDBM50128285 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774513 (CHEMBL1908730) |
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| Kd | 5300±n/a nM |
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| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 16 |
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| Name: | Cyclin-dependent kinase 16 |
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| Synonyms: | CDK16 | CDK16_HUMAN | PCTAIRE1 | PCTK1 | Serine/threonine-protein kinase PCTAIRE-1 |
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| Type: | Protein |
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| Mol. Mass.: | 55721.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00536 |
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| Residue: | 496 |
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| Sequence: | MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR
GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL
PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY
KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF
EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL
KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP
LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA
DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS
MPDSGRPAFRVVDTEF
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| BDBM50128285 |
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| n/a |
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| Name | BDBM50128285 |
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| Synonyms: | 3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione | CHEMBL300138 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H29N5O2 |
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| Mol. Mass. | 515.605 |
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| SMILES | Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccn4)CC3)c3ccccc23)c2ccccc12 |t:4| |
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| Structure | 
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