| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 5 |
|---|
| Ligand | BDBM50355504 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_774201 (CHEMBL1908418) |
|---|
| Kd | 2.5±n/a nM |
|---|
| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity mitogen-activated protein kinase kinase 5 |
|---|
| Name: | Dual specificity mitogen-activated protein kinase kinase 5 |
|---|
| Synonyms: | MAP kinase kinase 5 | MAP2K5 | MAPK/ERK kinase 5 | MAPKK 5 | MEK5 | MKK5 | MP2K5_HUMAN | PRKMK5 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50110.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1495740 |
|---|
| Residue: | 448 |
|---|
| Sequence: | MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ
KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
QFNDGNAAVVSMWVCRALEERRSQQGPP
|
|
|
|---|
| BDBM50355504 |
|---|
| n/a |
|---|
| Name | BDBM50355504 |
|---|
| Synonyms: | CHEMBL1908393 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H36F2N4O6 |
|---|
| Mol. Mass. | 634.6696 |
|---|
| SMILES | COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)NC4=CCC(F)C=C4)cc3F)ccnc2cc1OCCCN1CCOCC1 |c:26,t:21| |
|---|
| Structure | 
|
|---|
Search and Browse
