Ki Summary

Reaction Details

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Target

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Ligand

BDBM50128285

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_774304 (CHEMBL1908521)

>10000±n/a nM

Citation

Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Name:

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Synonyms:

PI51A_HUMAN | PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha

Type:

PROTEIN

Mol. Mass.:

62644.19

Organism:

Homo sapiens (Human)

Description:

ChEMBL_774304

Residue:

562

Sequence:

MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVLEARQDSYISLVPYASGMP
IKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIF
FPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASG
SLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIR
IVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADM
YNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALY
STAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWK
ALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSC
ITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGET
LQMLTTSTTLEKLEVAESEFTH

BDBM50128285

n/a

Name

BDBM50128285

Synonyms:

3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione | CHEMBL300138

Type

Small organic molecule

Emp. Form.

C32H29N5O2

Mol. Mass.

515.605

SMILES

Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccn4)CC3)c3ccccc23)c2ccccc12 |t:4|

Structure