| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Activin receptor type-2B |
|---|
| Ligand | BDBM31093 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_774300 (CHEMBL1908517) |
|---|
| Kd | >10000±n/a nM |
|---|
| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Activin receptor type-2B |
|---|
| Name: | Activin receptor type-2B |
|---|
| Synonyms: | ACVR2B | AVR2B_HUMAN | Activin receptor type-2B |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 57713.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_116734708 |
|---|
| Residue: | 512 |
|---|
| Sequence: | MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY
ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG
GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP
PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK
HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY
LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG
TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ
HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL
IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
|
|
|
|---|
| BDBM31093 |
|---|
| n/a |
|---|
| Name | BDBM31093 |
|---|
| Synonyms: | 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid | 4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid | BDBM31832 | CHEMBL259084 | MLN-8054 | cid_11712649 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H15ClF2N4O2 |
|---|
| Mol. Mass. | 476.862 |
|---|
| SMILES | OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 |c:13| |
|---|
| Structure | 
|
|---|
Search and Browse
