| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase tousled-like 1 |
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| Ligand | BDBM50132260 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774549 (CHEMBL1908766) |
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| Kd | >10000±n/a nM |
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| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase tousled-like 1 |
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| Name: | Serine/threonine-protein kinase tousled-like 1 |
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| Synonyms: | KIAA0137 | Serine/threonine-protein kinase tousled-like 1 | TLK1 | TLK1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 86722.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_33636698 |
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| Residue: | 766 |
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| Sequence: | MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQ
ELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESS
RGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTP
SSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRID
DLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRL
GHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAP
STNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAE
LERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQR
YAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEY
CEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTAC
GEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSV
GVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKE
DRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
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| BDBM50132260 |
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| n/a |
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| Name | BDBM50132260 |
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| Synonyms: | 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide | 2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide | CHEMBL105442 | CI-1040 | PD-18435 | PD-184352 | US8575391, 341 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14ClF2IN2O2 |
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| Mol. Mass. | 478.66 |
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| SMILES | Fc1ccc(C(=O)NOCC2CC2)c(Nc2ccc(I)cc2Cl)c1F |
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| Structure | 
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