Reaction Details |
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Target | Ribosomal protein S6 kinase alpha-2 |
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Ligand | BDBM13216 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_774607 (CHEMBL1908824) |
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Kd | >10000±n/a nM |
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Citation | Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ribosomal protein S6 kinase alpha-2 |
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Name: | Ribosomal protein S6 kinase alpha-2 |
Synonyms: | 90 kDa ribosomal protein S6 kinase 2 | 90 kDa ribosomal protein S6 kinase 2 (RSK2) | KS6A2_HUMAN | MAP kinase-activated protein kinase 1c | MAPKAPK1C | RPS6KA2 | RPS6KA2(Kin.Dom.1 - N-terminal) | RSK3 | Ribosomal S6 Kinase 3 (RSK-3) | Ribosomal protein S6 kinase alpha 2 | Ribosomal protein S6 kinase alpha 2 (RSK2) | Ribosomal protein S6 kinase alpha-2 | p90-RSK 2 | p90RSK | pp90RSK3 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 83259.46 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 733 |
Sequence: | MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFE
LLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPF
IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGI
IYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSA
DWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCN
RLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDS
PGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKED
IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK
FVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILY
RDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGIL
LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQR
LTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLA
QRRGMKRLTSTRL
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BDBM13216 |
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n/a |
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Name | BDBM13216 |
Synonyms: | BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide | N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | US10294227, Code Dasatinib | US20230348453, Compound A8 | cid_3062316 | med.21724, Compound Dasatinib |
Type | Small organic molecule |
Emp. Form. | C22H26ClN7O2S |
Mol. Mass. | 488.006 |
SMILES | Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 |
Structure |
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