Reaction Details |
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Target | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 |
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Ligand | BDBM50356009 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_775059 (CHEMBL1912254) |
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Ki | 300±n/a nM |
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Citation | Qian, Y; Ahmad, M; Chen, S; Gillespie, P; Le, N; Mennona, F; Mischke, S; So, SS; Wang, H; Burghardt, C; Tannu, S; Conde-Knape, K; Kochan, J; Bolin, D Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors. Bioorg Med Chem Lett21:6264-9 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 |
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Name: | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 |
Synonyms: | GFAT | GFPT | GFPT1 | GFPT1_HUMAN | Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1 |
Type: | PROTEIN |
Mol. Mass.: | 78813.10 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_775079 |
Residue: | 699 |
Sequence: | MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLI
KKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIV
IHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQ
LEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRW
GSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVA
AVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRG
RVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELAS
DFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGV
HINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLS
MDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLAL
VDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVD
CLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE
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BDBM50356009 |
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n/a |
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Name | BDBM50356009 |
Synonyms: | CHEMBL1911368 |
Type | Small organic molecule |
Emp. Form. | C23H23F3N2O6S |
Mol. Mass. | 512.499 |
SMILES | COc1cc2c(CNS(=O)(=O)C(F)(F)F)cnc(C(=O)c3cccc(OC(C)C)c3)c2cc1OC |
Structure |
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