| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 |
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| Ligand | BDBM50356012 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_775079 (CHEMBL1912274) |
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| IC50 | 120000±n/a nM |
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| Citation |  Qian, Y; Ahmad, M; Chen, S; Gillespie, P; Le, N; Mennona, F; Mischke, S; So, SS; Wang, H; Burghardt, C; Tannu, S; Conde-Knape, K; Kochan, J; Bolin, D Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors. Bioorg Med Chem Lett21:6264-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 |
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| Name: | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 |
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| Synonyms: | GFAT | GFPT | GFPT1 | GFPT1_HUMAN | Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78813.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_775079 |
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| Residue: | 699 |
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| Sequence: | MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLI
KKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIV
IHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQ
LEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRW
GSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVA
AVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRG
RVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELAS
DFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGV
HINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLS
MDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLAL
VDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVD
CLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE
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| BDBM50356012 |
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| n/a |
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| Name | BDBM50356012 |
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| Synonyms: | AAPTAMINE |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12N2O2 |
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| Mol. Mass. | 228.2466 |
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| SMILES | COc1cc2ccnc3cc[nH]c(c1OC)c23 |
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| Structure | 
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