Ki Summary

Reaction Details

Report a problem with these data

Target

Cannabinoid receptor 2

Ligand

BDBM50356536

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_776031 (CHEMBL1912501)

18.3±n/a nM

Citation

Piscitelli, F; Ligresti, A; La Regina, G; Gatti, V; Brizzi, A; Pasquini, S; Allarà, M; Carai, MA; Novellino, E; Colombo, G; Di Marzo, V; Corelli, F; Silvestri, R 1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: an effective scaffold for the design of either CB1 or CB2 receptor ligands. Eur J Med Chem46:5641-53 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cannabinoid receptor 2

Name:

Cannabinoid receptor 2

Synonyms:

CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

39690.94

Organism:

Homo sapiens (Human)

Description:

P34972

Residue:

360

Sequence:

MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC

BDBM50356536

n/a

Name

BDBM50356536

Synonyms:

CHEMBL1909844

Type

Small organic molecule

Emp. Form.

C21H21Cl3N4O

Mol. Mass.

451.777

SMILES

Cc1c(nn(c1-n1cccc1Cl)-c1ccc(Cl)cc1Cl)C(=O)NC1CCCCC1 |(7.22,3.84,;8.12,2.59,;9.66,2.59,;10.13,1.13,;8.89,.23,;7.64,1.13,;6.18,.66,;5.7,-.8,;4.16,-.8,;3.68,.67,;4.93,1.57,;4.94,3.11,;8.88,-1.31,;7.54,-2.08,;7.54,-3.62,;8.87,-4.39,;8.87,-5.93,;10.21,-3.61,;10.21,-2.08,;11.54,-1.31,;10.56,3.83,;9.94,5.24,;12.1,3.67,;13,4.92,;14.54,4.74,;15.45,5.98,;14.83,7.39,;13.3,7.56,;12.38,6.31,)|

Structure