Reaction Details | |||
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Target | Dipeptidyl peptidase 4 | ||
Ligand | BDBM50356595 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_776111 (CHEMBL1912807) | ||
Ki | 12±n/a nM | ||
Citation | Wang, W; Devasthale, P; Wang, A; Harrity, T; Egan, D; Morgan, N; Cap, M; Fura, A; Klei, HE; Kish, K; Weigelt, C; Sun, L; Levesque, P; Li, YX; Zahler, R; Kirby, MS; Hamann, LG 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site. Bioorg Med Chem Lett21:6646-51 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Dipeptidyl peptidase 4 | |||
Name: | Dipeptidyl peptidase 4 | ||
Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 | ||
Type: | Enzyme | ||
Mol. Mass.: | 88271.01 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P27487 | ||
Residue: | 766 | ||
Sequence: |
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BDBM50356595 | |||
n/a | |||
Name | BDBM50356595 | ||
Synonyms: | CHEMBL1910109 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H19Cl2N3OS | ||
Mol. Mass. | 444.377 | ||
SMILES | CSc1ccccc1N1Cc2c(nc(C)c(CN)c2-c2ccc(Cl)cc2Cl)C1=O |(15.43,-50.67,;16.2,-49.34,;15.43,-48.01,;13.89,-48.01,;13.11,-46.67,;13.89,-45.34,;15.43,-45.34,;16.19,-46.68,;17.73,-46.68,;18.63,-47.92,;20.09,-47.45,;20.1,-45.91,;21.42,-45.13,;22.76,-45.9,;24.09,-45.12,;22.76,-47.45,;24.1,-48.22,;25.43,-47.44,;21.43,-48.22,;21.43,-49.76,;20.09,-50.52,;20.09,-52.06,;21.43,-52.83,;21.43,-54.37,;22.77,-52.06,;22.76,-50.52,;24.09,-49.75,;18.63,-45.43,;18.16,-43.97,)| | ||
Structure |