Reaction Details | |||
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Target | Dipeptidyl peptidase 9 | ||
Ligand | BDBM50356588 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_776113 (CHEMBL1912809) | ||
Ki | 1536±n/a nM | ||
Citation | Wang, W; Devasthale, P; Wang, A; Harrity, T; Egan, D; Morgan, N; Cap, M; Fura, A; Klei, HE; Kish, K; Weigelt, C; Sun, L; Levesque, P; Li, YX; Zahler, R; Kirby, MS; Hamann, LG 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site. Bioorg Med Chem Lett21:6646-51 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Dipeptidyl peptidase 9 | |||
Name: | Dipeptidyl peptidase 9 | ||
Synonyms: | DPP9 | DPP9_HUMAN | DPRP-2 | DPRP2 | Dipeptidyl peptidase 9 (DDP9) | Dipeptidyl peptidase 9 (DPP-9) | Dipeptidyl peptidase 9 (DPP9) | Dipeptidyl peptidase IV-related protein 2 | Dipeptidyl peptidase IX | Dipeptidyl peptidase IX (DDP-IX) | Dipeptidyl peptidase-like protein 9 | ||
Type: | Enzyme | ||
Mol. Mass.: | 98260.70 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q86TI2 | ||
Residue: | 863 | ||
Sequence: |
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BDBM50356588 | |||
n/a | |||
Name | BDBM50356588 | ||
Synonyms: | CHEMBL1910120 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H25Cl2N5O3 | ||
Mol. Mass. | 490.382 | ||
SMILES | CC(=O)N1CCN(CC1)C(=O)CN1Cc2c(nc(C)c(CN)c2-c2ccc(Cl)cc2Cl)C1=O |(11.15,-31.36,;11.92,-32.69,;11.15,-34.03,;13.46,-32.7,;14.24,-31.37,;15.77,-31.37,;16.54,-32.7,;15.78,-34.04,;14.23,-34.03,;18.08,-32.7,;18.85,-34.03,;18.84,-31.36,;20.38,-31.36,;21.28,-32.61,;22.75,-32.13,;22.75,-30.6,;24.08,-29.82,;25.41,-30.58,;26.74,-29.81,;25.42,-32.13,;26.75,-32.9,;28.08,-32.13,;24.08,-32.91,;24.08,-34.44,;22.75,-35.21,;22.74,-36.75,;24.08,-37.52,;24.08,-39.06,;25.42,-36.74,;25.41,-35.21,;26.74,-34.43,;21.28,-30.12,;20.81,-28.65,)| | ||
Structure |