Reaction Details | |||
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Target | cGMP-specific 3',5'-cyclic phosphodiesterase | ||
Ligand | BDBM50357262 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_788276 (CHEMBL1919539) | ||
IC50 | 0.100000±n/a nM | ||
Citation | Hughes, RO; Maddux, T; Joseph Rogier, D; Lu, S; Walker, JK; Jon Jacobsen, E; Rumsey, JM; Zheng, Y; Macinnes, A; Bond, BR; Han, S Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region. Bioorg Med Chem Lett21:6348-52 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cGMP-specific 3',5'-cyclic phosphodiesterase | |||
Name: | cGMP-specific 3',5'-cyclic phosphodiesterase | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | CGB-PDE | PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase 2 and 5 (PDE2 and PDE5) | Phosphodiesterase 5 (PDE5) | Phosphodiesterase 5A | Phosphodiesterase 5A (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3',5'-cyclic phosphodiesterase | ||
Type: | Protein | ||
Mol. Mass.: | 99975.83 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O76074 | ||
Residue: | 875 | ||
Sequence: |
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BDBM50357262 | |||
n/a | |||
Name | BDBM50357262 | ||
Synonyms: | CHEMBL1916295 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H31N5O4 | ||
Mol. Mass. | 453.534 | ||
SMILES | CCCOCCn1c2cc(cnc2c(NC2CCC(O)CC2)nc1=O)-c1ccc(OC)nc1 |(25.6,-22.57,;24.26,-23.34,;22.93,-22.57,;21.6,-23.34,;21.6,-24.88,;20.26,-25.65,;20.26,-27.19,;21.59,-27.97,;22.91,-27.21,;24.24,-27.97,;24.25,-29.51,;22.92,-30.28,;21.59,-29.51,;20.26,-30.27,;20.26,-31.81,;18.93,-32.59,;17.6,-31.81,;16.27,-32.57,;16.27,-34.11,;14.93,-34.88,;17.6,-34.89,;18.94,-34.12,;18.93,-29.51,;18.93,-27.97,;17.6,-27.2,;25.57,-27.19,;25.56,-25.65,;26.89,-24.88,;28.23,-25.64,;29.56,-24.87,;30.9,-25.63,;28.23,-27.18,;26.9,-27.96,)| | ||
Structure |