Reaction Details | |||
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Target | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | ||
Ligand | BDBM50357820 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_787244 (CHEMBL1918966) | ||
IC50 | >10000±n/a nM | ||
Citation | Malamas, MS; Ni, Y; Erdei, J; Stange, H; Schindler, R; Lankau, HJ; Grunwald, C; Fan, KY; Parris, K; Langen, B; Egerland, U; Hage, T; Marquis, KL; Grauer, S; Brennan, J; Navarra, R; Graf, R; Harrison, BL; Robichaud, A; Kronbach, T; Pangalos, MN; Hoefgen, N; Brandon, NJ Highly potent, selective, and orally active phosphodiesterase 10A inhibitors. J Med Chem54:7621-38 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | |||
Name: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | ||
Synonyms: | High-affinity cAMP-specific and IBMX-insensitive 3 ,5 -cyclic phosphodiesterase 8A | PDE8A | PDE8A_HUMAN | Phosphodiesterase 8 | Phosphodiesterase 8 (PDE8) | Phosphodiesterase 8A (PDE8A) | Phosphodiesterase 8A (PDE8A1) | Phosphodiesterase 8A1 | Phosphodiesterase Type 8 (PDE8A) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 93295.89 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Recombinant catalytic domain (M1-E829) of human PDE8A. | ||
Residue: | 829 | ||
Sequence: |
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BDBM50357820 | |||
n/a | |||
Name | BDBM50357820 | ||
Synonyms: | CHEMBL1915910 | ||
Type | Small organic molecule | ||
Emp. Form. | C18H20N6O | ||
Mol. Mass. | 336.391 | ||
SMILES | COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 |(6.95,-22.59,;8.28,-23.36,;9.62,-22.59,;9.62,-21.05,;10.95,-20.28,;12.28,-21.04,;13.62,-20.25,;14.97,-21.03,;16.3,-20.25,;14.98,-22.58,;16.13,-23.63,;17.64,-23.31,;15.5,-25.05,;13.95,-24.89,;13.06,-26.14,;13.54,-27.6,;15.01,-28.07,;12.31,-28.52,;11.05,-27.62,;9.59,-28.11,;11.52,-26.15,;10.6,-24.92,;13.63,-23.36,;12.29,-22.59,;10.95,-23.36,)| | ||
Structure |