Reaction Details |
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Target | Histamine H1 receptor |
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Ligand | BDBM50419461 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_790127 (CHEMBL1926406) |
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Ki | 4168.69±n/a nM |
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Citation | de Graaf, C; Kooistra, AJ; Vischer, HF; Katritch, V; Kuijer, M; Shiroishi, M; Iwata, S; Shimamura, T; Stevens, RC; de Esch, IJ; Leurs, R Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor. J Med Chem54:8195-206 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H1 receptor |
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Name: | Histamine H1 receptor |
Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 55808.72 |
Organism: | Homo sapiens (Human) |
Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
Residue: | 487 |
Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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BDBM50419461 |
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n/a |
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Name | BDBM50419461 |
Synonyms: | CHEMBL1923531 |
Type | Small organic molecule |
Emp. Form. | C15H19N5 |
Mol. Mass. | 269.3449 |
SMILES | C(Cn1c2ccccc2n2ncnc12)N1CCCCC1 |
Structure |
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