| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glucagon receptor |
|---|
| Ligand | BDBM50358817 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_790196 (CHEMBL1925536) |
|---|
| IC50 | 28±n/a nM |
|---|
| Citation |  Sinz, C; Bittner, A; Brady, E; Candelore, M; Dallas-Yang, Q; Ding, V; Jiang, G; Lin, Z; Qureshi, S; Salituro, G; Saperstein, R; Shang, J; Szalkowski, D; Tota, L; Vincent, S; Wright, M; Xu, S; Yang, X; Zhang, B; Tata, J; Kim, R; Parmee, ER Discovery of N-aryl-2-acylindole human glucagon receptor antagonists. Bioorg Med Chem Lett21:7124-30 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glucagon receptor |
|---|
| Name: | Glucagon receptor |
|---|
| Synonyms: | GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54026.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P47871 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
|
|
|
|---|
| BDBM50358817 |
|---|
| n/a |
|---|
| Name | BDBM50358817 |
|---|
| Synonyms: | CHEMBL1922918 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H28ClF3N2O5 |
|---|
| Mol. Mass. | 601.013 |
|---|
| SMILES | CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc(OC(F)(F)F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
