| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM14712 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_792219 (CHEMBL1930746) |
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| IC50 | 26±n/a nM |
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| Citation |  Erra, M; Moreno, I; Sanahuja, J; Andrés, M; Reinoso, RF; Lozoya, E; Pizcueta, P; Godessart, N; Castro-Palomino, JC Biaryl analogues of teriflunomide as potent DHODH inhibitors. Bioorg Med Chem Lett21:7268-72 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHOdehase | Dhodh | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial precursor | Dihydroorotate oxidase | PYRD_RAT |
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| Type: | Enzyme |
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| Mol. Mass.: | 42672.97 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | The enzyme assay was performed with the histidine-tagged enzyme without cleavage of the tag. |
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| Residue: | 395 |
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| Sequence: | MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVR
VTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSV
TPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGIN
LGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQER
DALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIF
LGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR
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| BDBM14712 |
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| n/a |
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| Name | BDBM14712 |
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| Synonyms: | (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide | A77 1726 | CHEMBL973 | CHEMBL999 | TERIFLUNOMIDE |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9F3N2O2 |
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| Mol. Mass. | 270.2073 |
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| SMILES | CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F |
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| Structure | 
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