| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf |
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| Ligand | BDBM50360788 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_796661 (CHEMBL1937976) |
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| IC50 | 9640±n/a nM |
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| Citation |  Packard, GK; Papa, P; Riggs, JR; Erdman, P; Tehrani, L; Robinson, D; Harris, R; Shevlin, G; Perrin-Ninkovic, S; Hilgraf, R; McCarrick, MA; Tran, T; Fleming, Y; Bai, A; Richardson, S; Katz, J; Tang, Y; Leisten, J; Moghaddam, M; Cathers, B; Zhu, D; Sakata, S Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors. Bioorg Med Chem Lett22:747-52 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase B-raf |
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| Name: | Serine/threonine-protein kinase B-raf |
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| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 84446.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15056 |
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| Residue: | 766 |
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| Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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| BDBM50360788 |
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| n/a |
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| Name | BDBM50360788 |
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| Synonyms: | CHEMBL1934504 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17Cl2N5O2S |
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| Mol. Mass. | 426.32 |
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| SMILES | CC(C)(CO)Nc1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)c(sc2n1)C(N)=O |
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| Structure | 
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