| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50361012 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_795798 (CHEMBL1936685) |
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| Ki | 3300±n/a nM |
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| Citation |  Smits, RA; Lim, HD; van der Meer, T; Kuhne, S; Bessembinder, K; Zuiderveld, OP; Wijtmans, M; de Esch, IJ; Leurs, R Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics. Bioorg Med Chem Lett22:461-7 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | Bphs | HRH1_MOUSE | Hrh1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55705.87 |
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| Organism: | Mus musculus (mouse) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MSLPNTSSASEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLRYRTKTRASATILGAWFLSFLWVIPILGWHHFTPLAPELREDKC
ETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPTFLEIKLR
SEDAKEGAKKPGKESPWGVQKRPSRDPTGGLDQKSTSEDPKVTSPTVFSQEGERETVTRP
CFRLDVMQTQPVPEGDARGSKANDQTLSQPKMDEQSLSTCRRISETSEDQTLVDRQSFSR
TTDSDTSIEPGLGKVKARSRSNSGLDYIKVTWKRLRSHSRQYVSGLHLNRERKAAKQLGC
IMAAFILCWIPYFIFFMVIAFCNSCCSEPVHMFTIWLGYINSTLNPLIYPLCNENFKKTF
KKILHIRS
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| BDBM50361012 |
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| n/a |
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| Name | BDBM50361012 |
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| Synonyms: | CHEMBL1935574 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17N5O |
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| Mol. Mass. | 295.3391 |
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| SMILES | Nc1nc(N2CCNCC2)c2ccc(cc2n1)-c1ccco1 |
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| Structure | 
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