Ki Summary

Reaction Details

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Target

MAP kinase-activated protein kinase 2

Ligand

BDBM50362108

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_797472 (CHEMBL1943215)

IC50

4743±n/a nM

Citation

Huang, X; Zhu, X; Chen, X; Zhou, W; Xiao, D; Degrado, S; Aslanian, R; Fossetta, J; Lundell, D; Tian, F; Trivedi, P; Palani, A A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors. Bioorg Med Chem Lett22:65-70 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

MAP kinase-activated protein kinase 2

Name:

MAP kinase-activated protein kinase 2

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

45579.87

Organism:

Homo sapiens (Human)

Description:

P49137

Residue:

400

Sequence:

MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH

BDBM50362108

n/a

Name

BDBM50362108

Synonyms:

CHEMBL1940510

Type

Small organic molecule

Emp. Form.

C27H31ClN4O2

Mol. Mass.

479.014

SMILES

Clc1ccc(cc1)-c1ccc(o1)C(=O)N(Cc1ccccn1)C1CCC(CC1)N1CCNCC1 |(-.6,-7.34,;.94,-7.33,;1.7,-5.99,;3.24,-5.99,;4.01,-7.32,;3.25,-8.65,;1.72,-8.66,;5.55,-7.31,;6.47,-8.56,;7.93,-8.07,;7.93,-6.52,;6.46,-6.05,;9.26,-5.75,;9.25,-4.21,;10.59,-6.51,;10.6,-8.05,;11.94,-8.82,;11.93,-10.36,;13.27,-11.12,;14.6,-10.35,;14.59,-8.8,;13.25,-8.04,;11.92,-5.74,;13.26,-6.51,;14.59,-5.73,;14.58,-4.19,;13.24,-3.43,;11.91,-4.21,;15.91,-3.43,;17.25,-4.19,;18.57,-3.42,;18.57,-1.88,;17.24,-1.11,;15.9,-1.89,)|

Structure