| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B10 |
|---|
| Ligand | BDBM50362844 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_798534 (CHEMBL1942331) |
|---|
| IC50 | 13±n/a nM |
|---|
| Citation |  Soda, M; Hu, D; Endo, S; Takemura, M; Li, J; Wada, R; Ifuku, S; Zhao, HT; El-Kabbani, O; Ohta, S; Yamamura, K; Toyooka, N; Hara, A; Matsunaga, T Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10. Eur J Med Chem48:321-9 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldo-keto reductase family 1 member B10 |
|---|
| Name: | Aldo-keto reductase family 1 member B10 |
|---|
| Synonyms: | AK1BA_HUMAN | AKR1B10 | AKR1B11 | ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldo-keto reductase family member 1B10 (AKR1B10) | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36024.67 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60218. 1ZUA; 4JII; 4GQ0 |
|---|
| Residue: | 316 |
|---|
| Sequence: | MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQ
EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD
DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN
VLQSSHLEDYPFNAEY
|
|
|
|---|
| BDBM50362844 |
|---|
| n/a |
|---|
| Name | BDBM50362844 |
|---|
| Synonyms: | CHEMBL1940396 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H18O5 |
|---|
| Mol. Mass. | 314.3325 |
|---|
| SMILES | COc1cc(O)ccc1\C=C\C(=O)OCCc1cccc(O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
