| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50331754 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_802754 (CHEMBL1953400) |
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| IC50 | 126±n/a nM |
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| Citation |  Thompson, CF; Ali, A; Quraishi, N; Lu, Z; Hammond, ML; Sinclair, PJ; Anderson, MS; Eveland, SS; Guo, Q; Hyland, SA; Milot, DP; Sparrow, CP; Wright, SD Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein. ACS Med Chem Lett2:424-427 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50331754 |
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| n/a |
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| Name | BDBM50331754 |
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| Synonyms: | CHEMBL1288516 | methyl 3,5-bis(trifluoromethyl)benzyl((5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)carbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C29H26F9NO3 |
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| Mol. Mass. | 607.5073 |
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| SMILES | COC(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1cc(ccc1-c1cc(ccc1OC)C(C)C)C(F)(F)F |
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| Structure | 
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