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TargetAcyl-CoA desaturase 1
LigandBDBM50364037
Substrate/Competitorn/a
Meas. Tech.ChEMBL_805304 (CHEMBL1955197)
IC50 248±n/a nM
Citation Lachance, NGuiral, SHuang, ZLeclerc, JPLi, CSOballa, RMRamtohul, YKWang, HWu, JZhang, L Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series. Bioorg Med Chem Lett22:623-7 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Acyl-CoA desaturase 1
Name:Acyl-CoA desaturase 1
Synonyms:ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1)
Type:Enzyme
Mol. Mass.:41485.97
Organism:Rattus norvegicus (Rat)
Description:P07308
Residue:358
Sequence:
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50364037
n/a
NameBDBM50364037
Synonyms:CHEMBL1950547
TypeSmall organic molecule
Emp. Form.C16H15BrFN5O5
Mol. Mass.456.223
SMILESOC(=O)Cn1nnc(n1)-c1cc(OCCCCOc2cc(F)ccc2Br)no1
Structure
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