| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
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| Ligand | BDBM50364041 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_805304 (CHEMBL1955197) |
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| IC50 | 2±n/a nM |
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| Citation |  Lachance, N; Guiral, S; Huang, Z; Leclerc, JP; Li, CS; Oballa, RM; Ramtohul, YK; Wang, H; Wu, J; Zhang, L Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series. Bioorg Med Chem Lett22:623-7 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA desaturase 1 |
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| Name: | Acyl-CoA desaturase 1 |
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| Synonyms: | ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41485.97 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P07308 |
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| Residue: | 358 |
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| Sequence: | MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
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| BDBM50364041 |
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| n/a |
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| Name | BDBM50364041 |
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| Synonyms: | CHEMBL1950551 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13BrF3N5O5S |
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| Mol. Mass. | 524.269 |
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| SMILES | OC(=O)Cn1nnc(n1)-c1cnc(OCCCOc2cc(OC(F)(F)F)ccc2Br)s1 |
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| Structure | 
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