| Reaction Details |
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 | Report a problem with these data |
| Target | Glucose-dependent insulinotropic receptor |
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| Ligand | BDBM50364541 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_802832 (CHEMBL1953650) |
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| EC50 | 55±n/a nM |
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| Citation |  Semple, G; Lehmann, J; Wong, A; Ren, A; Bruce, M; Shin, YJ; Sage, CR; Morgan, M; Chen, WC; Sebring, K; Chu, ZL; Leonard, JN; Al-Shamma, H; Grottick, AJ; Du, F; Liang, Y; Demarest, K; Jones, RM Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile. Bioorg Med Chem Lett22:1750-5 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucose-dependent insulinotropic receptor |
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| Name: | Glucose-dependent insulinotropic receptor |
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| Synonyms: | GP119_RAT | Gpr119 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51687.59 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1506411 |
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| Residue: | 468 |
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| Sequence: | MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISG
LVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGL
VAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLL
FVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSP
FLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLAD
GSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLY
TCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDA
QTLYTCDAQTLYTCDAQTLYTSSLVTGQTEQTPLKRANMSDPLRTCRG
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| BDBM50364541 |
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| n/a |
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| Name | BDBM50364541 |
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| Synonyms: | CHEMBL1951011 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26FN3O6S |
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| Mol. Mass. | 467.511 |
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| SMILES | CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(cc2F)S(C)(=O)=O)c1C |
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| Structure | 
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