| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RAC-gamma serine/threonine-protein kinase |
|---|
| Ligand | BDBM50365218 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_807422 (CHEMBL1960793) |
|---|
| IC50 | 1290±n/a nM |
|---|
| Citation |  Doe, C; Bentley, R; Behm, DJ; Lafferty, R; Stavenger, R; Jung, D; Bamford, M; Panchal, T; Grygielko, E; Wright, LL; Smith, GK; Chen, Z; Webb, C; Khandekar, S; Yi, T; Kirkpatrick, R; Dul, E; Jolivette, L; Marino, JP; Willette, R; Lee, D; Hu, E Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther320:89-98 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RAC-gamma serine/threonine-protein kinase |
|---|
| Name: | RAC-gamma serine/threonine-protein kinase |
|---|
| Synonyms: | AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55769.36 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 479 |
|---|
| Sequence: | MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
|
|
|
|---|
| BDBM50365218 |
|---|
| n/a |
|---|
| Name | BDBM50365218 |
|---|
| Synonyms: | CHEMBL1956071 | GSK screening, 29 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H18N8O2 |
|---|
| Mol. Mass. | 342.3558 |
|---|
| SMILES | CCn1c(nc2cncc(C(=O)N3CC[C@H](N)C3)c12)-c1nonc1N |
|---|
| Structure | 
|
|---|
Search and Browse
