| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM50365218 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_807423 (CHEMBL1960794) |
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| IC50 | 7000±n/a nM |
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| Citation |  Doe, C; Bentley, R; Behm, DJ; Lafferty, R; Stavenger, R; Jung, D; Bamford, M; Panchal, T; Grygielko, E; Wright, LL; Smith, GK; Chen, Z; Webb, C; Khandekar, S; Yi, T; Kirkpatrick, R; Dul, E; Jolivette, L; Marino, JP; Willette, R; Lee, D; Hu, E Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther320:89-98 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM50365218 |
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| n/a |
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| Name | BDBM50365218 |
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| Synonyms: | CHEMBL1956071 | GSK screening, 29 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18N8O2 |
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| Mol. Mass. | 342.3558 |
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| SMILES | CCn1c(nc2cncc(C(=O)N3CC[C@H](N)C3)c12)-c1nonc1N |
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| Structure | 
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